BIRC2 baculoviral IAP repeat containing 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BIRC2provided by HGNC
Official Full Name: baculoviral IAP repeat containing 2provided by HGNC
Primary source: HGNC:HGNC:590
See related: Ensembl:ENSG00000110330 MIM:601712; AllianceGenome:HGNC:590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1
Summary: The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression: Ubiquitous expression in lymph node (RPKM 16.6), gall bladder (RPKM 15.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q22.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (102347214..102378670)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (102345302..102380795)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (102217945..102249401)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.
Title: BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.
Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head and Neck Squamous Cell Carcinoma.
Title: Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head and Neck Squamous Cell Carcinoma.
Cytoplasmic and Nuclear Functions of cIAP1.
Title: Cytoplasmic and Nuclear Functions of cIAP1.
BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.
Title: BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.
Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
Title: Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
Inhibition of BIRC2 Sensitizes alpha7-HPV-Related Cervical Squamous Cell Carcinoma to Chemotherapy.
Title: Inhibition of BIRC2 Sensitizes α7-HPV-Related Cervical Squamous Cell Carcinoma to Chemotherapy.
Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer.
Title: Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer.
BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy.
Title: BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy.
Stabilization of C-terminal binding protein 2 by cellular inhibitor of apoptosis protein 1 via BIR domains without E3 ligase activity.
Title: Stabilization of C-terminal binding protein 2 by cellular inhibitor of apoptosis protein 1 via BIR domains without E3 ligase activity.
Future Therapeutic Directions for Smac-Mimetics.
Title: Future Therapeutic Directions for Smac-Mimetics.

Submit: New GeneRIF Correction See all GeneRIFs (151)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of baculoviral IAP repeat containing 2 (BIRC2) in human B cells	PubMed
Vpr	vpr	Anti-apoptotic proteins cIAP1 and cIAP2 contribute to macrophage protection against HIV-1 Vpr-induced apoptosis	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH11632 (e-PCR)
- UniSTS:4102

WI-18122 (e-PCR)
- UniSTS:13132

A002E11 (e-PCR)
- UniSTS:30555

RH98380 (e-PCR)
- UniSTS:87905

D11S4286 (e-PCR)
- UniSTS:52606

PMC166414P1 (e-PCR)
- UniSTS:271590

SHGC-84924 (e-PCR)
- UniSTS:104955

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables FBXO family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	EXP Inferred from Experiment more info	PubMed
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	EXP Inferred from Experiment more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in canonical NF-kappaB signal transduction	TAS Traceable Author Statement more info
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in necroptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of necroptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ripoptosome assembly involved in necroptotic process	IEA Inferred from Electronic Annotation more info
involved_in non-canonical NF-kappaB signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in placenta development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein K63-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of RIG-I signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cysteine-type endopeptidase activity	TAS Traceable Author Statement more info	PubMed
involved_in regulation of inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in regulation of innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in regulation of necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of necroptotic process	TAS Traceable Author Statement more info
involved_in regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of toll-like receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
part_of CD40 receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in XY body	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 2

Names: IAP homolog B; IAP-2; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2; apoptosis inhibitor 1; cellular inhibitor of apoptosis 1; inhibitor of apoptosis protein 2

NP_001157.1

EC 2.3.2.27

NP_001243092.1

EC 2.3.2.27

NP_001243095.1

EC 2.3.2.27

XP_054224586.1

EC 2.3.2.27

XP_054224587.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166.5 → NP_001157.1 baculoviral IAP repeat-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_001157.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the predominant transcript. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AP000942

Consensus CDS

CCDS8316.1

UniProtKB/Swiss-Prot

B4E026, Q13490, Q16516, Q4TTG0

UniProtKB/TrEMBL

B2R8N8

Related

ENSP00000227758.2, ENST00000227758.7

Conserved Domains (5) summary

smart00238
Location:268 → 336

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:49 → 115

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd08329
Location:453 → 544

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:391 → 437

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:565 → 618

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
NM_001256163.1 → NP_001243092.1 baculoviral IAP repeat-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_001243092.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

BC028578, DA094075

Consensus CDS

CCDS8316.1

UniProtKB/Swiss-Prot

B4E026, Q13490, Q16516, Q4TTG0

UniProtKB/TrEMBL

B2R8N8

Related

ENSP00000477613.1, ENST00000613397.4

Conserved Domains (5) summary

smart00238
Location:268 → 336

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:49 → 115

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd08329
Location:453 → 544

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:391 → 437

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:565 → 618

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
NM_001256166.2 → NP_001243095.1 baculoviral IAP repeat-containing protein 2 isoform 2

See identical proteins and their annotated locations for NP_001243095.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate splice site in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AK303197, BC028578, DA115985

Consensus CDS

CCDS58169.1

UniProtKB/TrEMBL

E9PMH5

Related

ENSP00000431723.1, ENST00000530675.5

Conserved Domains (5) summary

smart00238
Location:219 → 287

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:1 → 66

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd08329
Location:404 → 495

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:342 → 388

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

pfam13920
Location:518 → 563

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

102347214..102378670

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

102345302..102380795

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054368612.1 → XP_054224587.1 baculoviral IAP repeat-containing protein 2 isoform X1
XM_054368611.1 → XP_054224586.1 baculoviral IAP repeat-containing protein 2 isoform X1